hrp0095p1-266 | Fat, Metabolism and Obesity | ESPE2022

Changes in hypothalamic functional connectivity in the brain following childhood-onset craniopharyngioma

Hinton Elanor , Elsworth Rebecca , Bedford Holly , Hawton Katherine , Narayan Kruthika , Naeem Nimra , Elson Ruth , Taylor-Miller Tashunka , Lithander Fiona , Hamilton-Shield Julian , Crowne Elizabeth

Background: Craniopharyngioma is a non-malignant, embryological brain tumour in the sellar and parasellar region. Hypothalamic damage is common and accompanied by development of obesity in at least 50% of cases. Mechanisms underlying hypothalamic obesity in craniopharyngioma patients however remain unclear and treatment options are invasive and limited. This feasibility study included a novel application of functional neuroimaging, an established method in obe...